Interferon-γ Induces p11 Gene and Protein Expression in Human Epithelial Cells through Interferon-γ-activated Sequences in the p11Promoter
نویسندگان
چکیده
منابع مشابه
Interferon- Induces p11 Gene and Protein Expression in Human Epithelial Cells through Interferon- -activated Sequences in the p11 Promoter*
The effect of interferon (IFN)on p11 expression was studied in two human epithelial cell lines (BEAS-2B and HeLa). Treatment with IFNresulted in increased steady-state levels of p11 mRNA and protein expression, with a time-dependent and dose-dependent effect. Transient transfection experiments of a reporter gene construct containing 1498 bp of the 5 -flanking region of the p11 promoter demonstr...
متن کاملInterferon-γ Upregulates Expression of IFP35 Gene in HeLa Cells via Interferon Regulatory Factor-1
BACKGROUND Interferon-induced 35-kDa protein (IFP35) plays important roles in antiviral defense and the progression of some skin cancer diseases. It can be induced by interferon-γ (IFN-γ) in multiple human cells. However, the mechanisms by which IFN-γ contributes to IFP35 induction remain to be elucidated. METHODS/PRINCIPAL FINDINGS We identified the transcription start sites of IFP35 by 5' r...
متن کاملInterferon-γ Induces Senescence in Normal Human Melanocytes
BACKGROUND Interferon-γ (IFN-γ) plays an important role in the proceedings of vitiligo through recruiting lymphocytes to the lesional skin. However, the potential effects of IFN-γ on skin melanocytes and the subsequent contribution to the vitiligo pathogenesis are still unclear. OBJECTIVE To investigate the effects of IFN-γ on viability and cellular functions of melanocytes. METHODS Primary...
متن کاملCurcumin inhibits interferon-γ signaling in colonic epithelial cells.
Curcumin (diferulolylmethane) is an anti-inflammatory phenolic compound found effective in preclinical models of inflammatory bowel diseases (IBD) and in ulcerative colitis patients. Pharmacokinetics of curcumin and its poor systemic bioavailability suggest that it targets preferentially intestinal epithelial cells. The intestinal epithelium, an essential component of the gut innate defense mec...
متن کاملHepcidin expression in human airway epithelial cells is regulated by interferon-γ
BACKGROUND Hepcidin serves as a major regulator of systemic iron metabolism and immune function. Airway epithelial cells have an extensive interface with the environment, and so must be able to respond locally to the presence of particulates, infection, and inflammation. Therefore, we hypothesized that hepcidin is expressed in airway epithelial cells and is regulated by early phase cytokines. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m212704200